The National Center for Biomedical Ontology is a consortium that comprises leading informaticians, biologists, clinicians, and ontologists, funded by the National Institutes of Health (NIH) Roadmap, to develop innovative technology and methods that allow scientists to record, manage, and disseminate biomedical information and knowledge in machine-processable form. The goals of the Center are (1) to help unify the divergent and isolated efforts in ontology development by promoting high quality open-source, standards-based tools to create, manage, and use ontologies, (2) to create (...) new software tools so that scientists can use ontologies to annotate and analyze biomedical data, (3) to provide a national resource for the ongoing evaluation, integration, and evolution of biomedical ontologies and associated tools and theories in the context of driving biomedical projects (DBPs), and (4) to disseminate the tools and resources of the Center and to identify, evaluate, and communicate best practices of ontology development to the biomedical community. Through the research activities within the Center, collaborations with the DBPs, and interactions with the biomedical community, our goal is to help scientists to work more effectively in the e-science paradigm, enhancing experiment design, experiment execution, data analysis, information synthesis, hypothesis generation and testing, and understand human disease. (shrink)

Cognitive science is the project of understanding the mind by modelling its workings. Its development is one of the most remarkable and fascinating intellectual achievements of the modern era. Mind as Machine is a masterful history of cognitive science, told by one of its most eminent practitioners.

There is increasing public interest in understanding the nature of corporate ethics due to the knowledge that unethical decisions and activities frequently undermine the performance and abilities of many organizations. Of the current literature found on the topic of ways organizations can influence ethical behavior, a majority is found on the issue of corporate codes of ethics.Most discussions on codes of ethics evaluate the contents of the codes and offer opinions on their wording, content, and/or value. Unfortunately, very little research (...) has been devoted towards discovering whether they are effective in promoting ethical decision-making behavior. Thus, due to the lack of empirical research on this particular topic, this paper attempts to further address this issue. (shrink)

Proponents of ground, which is used to indicate relations of ontological fundamentality, insist that ground is a unified phenomenon, but this thesis has recently been criticized. I will first review the proponents' claims for ground's unicity, as well as the criticisms that ground is too heterogeneous to do the philosophical work it is supposed to do. By drawing on Aristotle's notion of homonymy, I explore whether ground's metaphysical heterogeneity can be theoretically accommodated while at the same time preserving its proponents' (...) desideratum that it be a unified phenomenon. (shrink)

This paper provides an overview of corporate social responsibility in Brazil, a country of vast regional and economic differences. Despite abundant natural resources and centers of advanced technology, large numbers of Brazilians live in poverty. Historical factors, which to some extent explain Brazil’s social and economic inequalities – a long period of colonialism, followed by populist reform, repressive military measures, foreign debt, unfair trade agreements, and problems of corruption – have persisted into the current period of democratic reform, marked by (...) economic and political trends toward democratization and corporate social responsibility. This paper considers the civic and business organizations that have been developing strategies to encourage social responsibility and government policies aimed at alleviating poverty. Despite progress, the complexity of the Brazilian context presents challenges for social and economic equality. (shrink)

This study examines how Caterpillar Brasil Limitada, located in the city of Piracicaba, Brazil, expanded its concept of social responsibility over a 30-year period. It first provides a contextual overview of Piracicaba within the agro-industrialized interior region of São Paulo State. It then traces the history of the firm from its initial installation in the city. While Caterpillar maintained a distant relationship with the Piracicaba community for many years, it later realized the importance of becoming involved in city development. The (...) community-based effort led by Caterpillar to elaborate and carry out a sustainable development plan for the city is a notable example of how a firm can encourage civil participation and offer strategic planning know-how to civil-society organizations. Finally, the study analyses some of the problems Caterpillar encountered and stresses the importance of developing open democratic channels and continued civil participation in joint partnerships between business and civil society. (shrink)

The development of genetically modified organisms (GMOs) has caused worldwide debate and has required us to reevaluate theories of social responsibility. This article, first, briefly discusses the progressive stages of social responsibility that scholars have outlined as they examine the history of businesses. Next an overview of the development of the DuPont corporation in the United States is presented, tracing DuPont’s transformation from an explosives and chemicals company into a life-science corporation and demonstrating how outside factors influenced this change. The (...) article then turns to the activities of the DuPont corporation in Brazil, a country with one of the world’s largest agricultural economies – and examines how the debate on GMOs is unfolding within the Brazilian context. It discusses how differing interest groups have taken part in this debate, the limits of their arguments, and the need to develop means for providing open collaborative efforts in evaluating new technologies. (shrink)

Ethical decisions related to computer technology and computer use are subject to three primary influences: (1) the individual's own personal code (2) any informal code of ethical behavior that exists in the work place, and (3) exposure to formal codes of ethics. The relative importance of these codes, as well as factors influencing these codes, was explored in a nationwide survey of information system (IS) professionals. The implications of the findings are important to educators and employers in the development of (...) acceptable ethical standards. (shrink)

When faced with an ambiguous ethical situation related to computer technology (CT), the individual's course of action is influenced by personal experiences and opinions, consideration of what co-workers would do in the same situation, and an expectation of what the organization might sanction. In this article, the judgement of over three-hundred Association of Information Technology Professionals (AITP) members concerning the actions taken in a series of CT ethical scenarios are examined. Respondents expressed their personal judgement, as well as their perception (...) of their co-workers' judgement, and their understanding of the organization's judgement of the actions described in the scenarios. The findings show that there are differences in respondents' judgements for self, co-workers, and organization. Definitive patterns were also found between groups with and without organizational codes related to CT. (shrink)

This study examines how Caterpillar Brasil Limitada, located in the city of Piracicaba, Brazil, expanded its concept of social responsibility over a 30-year period. It first provides a contextual overview of Piracicaba within the agro-industrialized interior region of São Paulo State. It then traces the history of the firm from its initial installation in the city. While Caterpillar maintained a distant relationship with the Piracicaba community for many years, it later realized the importance of becoming involved in city development. The (...) community-based effort led by Caterpillar to elaborate and carry out a sustainable development plan for the city is a notable example of how a firm can encourage civil participation and offer strategic planning know-how to civil-society organizations. Finally, the study analyses some of the problems Caterpillar encountered and stresses the importance of developing open democratic channels and continued civil participation in joint partnerships between business and civil society. (shrink)

The National Center for Biomedical Ontology is now in its seventh year. The goals of this National Center for Biomedical Computing are to: create and maintain a repository of biomedical ontologies and terminologies; build tools and web services to enable the use of ontologies and terminologies in clinical and translational research; educate their trainees and the scientific community broadly about biomedical ontology and ontology-based technology and best practices; and collaborate with a variety of groups who develop and use ontologies and (...) terminologies in biomedicine. The centerpiece of the National Center for Biomedical Ontology is a web-based resource known as BioPortal. BioPortal makes available for research in computationally useful forms more than 270 of the world's biomedical ontologies and terminologies, and supports a wide range of web services that enable investigators to use the ontologies to annotate and retrieve data, to generate value sets and special-purpose lexicons, and to perform advanced analytics on a wide range of biomedical data. (shrink)

A dual-code model of number processing needs to take into account the difference between a number symbol and its meaning. The transition of automatic non-abstract number representations into intentional abstract representations could be conceptualized as a translation of perceptual asemantic representations of numerals into semantic representations of the associated magnitude information. The controversy about the nature of number representations should be thus related to theories on embodied grounding of symbols.

Anne Margaret Baxley offers a systematic interpretation of Kant's theory of virtue, whose most distinctive features have not been properly understood. She explores the rich moral psychology in Kant's later and less widely read works on ethics, and argues that the key to understanding his account of virtue is the concept of autocracy, a form of moral self-government in which reason rules over sensibility. Although certain aspects of Kant's theory bear comparison to more familiar Aristotelian claims about virtue, (...) Baxley contends that its most important aspects combine to produce something different - a distinctively modern, egalitarian conception of virtue which is an important and overlooked alternative to the more traditional Greek views which have dominated contemporary virtue ethics. (shrink)

In this volume, leading philosophers of psychiatry examine psychiatric classification systems, including the Diagnostic and Statistical Manual of Mental Disorders, asking whether current systems are sufficient for effective diagnosis, treatment, and research. Doing so, they take up the question of whether mental disorders are natural kinds, grounded in something in the outside world. Psychiatric categories based on natural kinds should group phenomena in such a way that they are subject to the same type of causal explanations and respond similarly to (...) the same type of causal interventions. When these categories do not evince such groupings, there is reason to revise existing classifications. The contributors all question current psychiatric classifications systems and the assumptions on which they are based. They differ, however, as to why and to what extent the categories are inadequate and how to address the problem. Topics discussed include taxometric methods for identifying natural kinds, the error and bias inherent in DSM categories, and the complexities involved in classifying such specific mental disorders as "oppositional defiance disorder" and pathological gambling. -/- Contributors George Graham, Nick Haslam, Allan Horwitz, Harold Kincaid, Dominic Murphy, Jeffrey Poland, Nancy Nyquist Potter, Don Ross, Dan Stein, Jacqueline Sullivan, Serife Tekin, Peter Zachar. (shrink)

Philosophers often mention Friedrich Schiller as the author of a famous epigram taking aim at Kant’s account of moral motivation: Gladly I serve my friends, but alas I do it with pleasure. Hence I am plagued with doubt that I am not a virtuous person. To this, the answer is given: Surely, your only resource is to try to despise them entirely, And then with aversion do what your duty enjoins. These joking lines capture a natural objection to Kant’s rationalist (...) picture of moral motivation, especially as it appears in the Groundwork of the Metaphysics of Morals. Schiller himself, however, intended his poem as a caricature of Kant’s view, reserving his considered critique of Kant’s practical philosophy for his extended treatise ‘On Grace and Dignity’. It is in this major work that Schiller begins his debate with Kant about the aesthetic aspect of morality, sets out a systematic account of his own ethics, and argues for an account of character according to which the virtuous person is inclined to do her duty and takes pleasure in moral action. This essay aims to highlight the importance of Schiller’s ‘On Grace and Dignity’, which is a valuable resource in relation to contemporary debates about Kant’s moral psychology. Section 1 outlines the main features of Schiller’s concerns with Kantian rationalism. Section 2 surveys a number of recent critical discussions of Schiller’s interpretation of Kant. Finally, Section 3 concludes with some observations about the historical and broader philosophical significance of ‘On Grace and Dignity’. (shrink)

In his extended essay "On Grace and Dignity," Friedrich Schiller sets out an important challenge to Kant when he argues that sensibility must play a constitutive role in the ethical life. This paper argues that there is much we can learn from Schiller's "corrective" to Kant's moral theory and Kant's reply to this critique, for what is at stake in their debate are rival conceptions of the proper state of moral health for us as finite rational beings and competing political (...) notions concerning the ideal form of self-governance that we ought to strive to attain. (shrink)

As analysis of Kant’s account of virtue in the Lectures on Ethics shows that Kant thinks of virtue as a form of moral self-mastery or self-command that represents a model of self-governance he compares to an autocracy. In light of the fact that the very concept of virtue presupposes struggle and conflict, Kant insists that virtue is distinct from holiness and that any ideal of moral perfection that overlooks the fact that morality is always difficult for us fails to provide (...) an appropriate model of human virtue. No matter how morally good we are or become, virtue remains a disposition to do one’s duty from duty, out of necessitation by practical reason. Yet, even though finite rational beings require a power of self-constraint in accordance with the commands of duty to comply with the law (which we obey reluctantly), the virtuous agent displays a unified soul that is at peace. This picture of virtue uncovered from the Lectures on Ethics thus reveals the way in which Kant’s conception of virtue accords with his foundational commitments in his moral theory, while at the same time representing a more complex theory of moral character and a life lived in accordance with practical reason. (shrink)

Kant's most familiar and widely read works in practical reason are the Groundwork of the Metaphysics of Morals (1785) and the Critique of Practical Reason (1788). His principal aims in these works are to analyze the nature and ground of morality and to justify its supreme principle (the categorical imperative). Nevertheless, in these texts, Kant also paints a picture of what it means to have a good will or good character, and it is this account of the good will and (...) the associated theory of moral motivation that have been the target of many of the historical and contemporary objections to Kant's rationalism. From the perspective of these foundational works in Kant's moral theory, it appears that all that is required for Kantian character is a firm commitment to do one's duty from the motive of duty in the absence of inclination, or in the teeth of countervailing inclination. Kant's defenders have rightly insisted that it would be hasty to draw any final conclusions about his considered views on character and moral psychology on the basis of the Groundwork and the second Critique. An adequate assessment of these kinds of charges against Kant, they have argued, must address his theory of virtue, as it is set out in his other important ethical texts, especially the Doctrine of Virtue (1797) and Religion Within the Boundaries of Mere Reason (1793). In his theory of virtue, Kant presents a detailed account of virtue as a character trait, provides lengthy discussions of the various virtues he sees as central for the ethical life, and maintains that there are moral feelings that are part of a virtuous character and serviceable for morality. For these reasons, those interested in gleaning a more complete picture of Kant's ethics await a detailed, systematic account of Kant's views about virtue. This entry aims to sketch the outlines of such an account. (shrink)

This account of the good will has struck many readers as counterintuitive. Whereas Kant seems to think that the person in whom a sense of duty must overcome indifference or contrary inclination can and does display a good will, our intuitions about human goodness suggest that there is something deficient or lacking in the grudging agent. Aristotle, for example, would think that the grudging moralist displays continence, rather than virtue, because he thinks it is the mark of the virtuous person (...) that he does not experience a conflict between the rational and nonrational parts of the soul and that his emotions and appetites harmonize with rational judgments. (shrink)

Aristotle famously held that there is a crucial difference between the person who merely acts rightly and the person who is wholehearted in what she does. He captures this contrast by insisting on a distinction between continence and full virtue. One way of accounting for the important difference here is to suppose that, for the genuinely virtuous person, the requirements of virtue "silence" competing reasons for action. I argue that the silencing interpretation is not compelling. As Aristotle rightly saw, virtue (...) can have a cost, and a mark of the wise person is that she recognizes it. (shrink)

The notion of virtue in general, and courage in particular, has had a hard time integrating itself into the everyday lexicon of bioethics. Following the lead of enlightenment moral philosophy, which concentrates on the theory of right action as opposed to the ancient Greeks' emphasis on the development of good character, bioethics, with some notable exceptions, has tended to relegate consideration of the virtues to the sidelines of moral argument. Recently, however, there have been calls for the necessity of “moral (...) courage” in the context of clinical ethics. As nurses, physicians, and other health care professionals confront a variety of moral contexts in which the virtue of courage is invoked to "do the right thing," stand up for patients' rights, and uphold the ethical standards of their professions, they are increasingly reminded of their moral duty to exhibit courage in the face of institutional obstacles to the proper care of their patients. For example, a nurse's hesitation to approach a physician to request increased sedation for an agitated patient out of fear of retaliation is represented in one article as a lack of courage.In this paper we offer a critical assessment of such invocations of courage. While we find courage to be an indispensable virtue in some challenging contexts, in other settings we find invocations of courage to be both an unfortunate endorsement of an oppressive status quo that can divert attention from the real problems and an undesirable and potentially destructive strategy within health care institutions whose goal is medically excellent and morally good clinical practice. As we shall argue, a call to virtuousness is not always virtuous. (shrink)

Though much progress has been made on inclusion of non-pregnant women in research, thoughtful discussion about including pregnant women has lagged behind. We outline resulting knowledge gaps and their costs and then highlight four reasons why ethically we are obliged to confront the challenges of including pregnant women in clinical research. These are: the need for effective treatment for women during pregnancy, fetal safety, harm from the reticence to prescribe potentially beneficial medication, and the broader issues of justice and access (...) to benefits of research participation. Going forward requires shifting the burden of justification from inclusion to exclusion and developing an adequate ethical framework that specifies suitable justifications for excluding pregnant women from research. (shrink)

Reasoning well about risk is most challenging when a woman is pregnant, for patient and doctor alike. During pregnancy, we tend to note the risks of medical interventions without adequately noting those of failing to intervene, yet when it's time to give birth, interventions are seldom questioned, even when they don't work. Meanwhile, outside the clinic, advice given to pregnant women on how to stay healthy in everyday life can seem capricious and overly cautious. This kind of reasoning reflects fear, (...) not evidence. (shrink)

When we speak about the aim of doing philosophy on the elementary school level with children as transforming classrooms into 'communities of inquiry', we make certain assumptions about nature and personhood and the relationship between the two. We also make certain assumptions about dialogue, truth and knowledge. Further, we make assumptions regarding the ability of children to form such communities that will engender care for one another as persons with rights, a tolerance for each other's views, feelings, imaginings, creations as (...) well as a care for one another's happiness equal to the concern one has for one's own happiness. Lastly, we make assumptions about children's ability to commit themselves to objectivity, impartiality, consistency and reasonableness. The latter has social, moral and political implications. This paper is an attempt to identify and clarify some of these assumptions. (shrink)

Life comes from physical or biological survival. But the good life comes from what we care about, what we value, what we think truly important, as distinguished from what we think merely trivial. What we care about is the source of the criteria we use to evaluate ideas, ideals, persons, events, things, and their importance in our lives. And it is these criteria that determine the judgments we make in our everyday lives. In the second edition of Thinking in Education, (...) Matthew Lipman has indicated the importance of fostering critical, creative and caring thinking in children, if one is to prepare them to make better judgments and live qualitatively better lives. He tells us that caring thinking is appreciative thinking, active thinking, normative thinking, affective thinking and empathetic thinking and then goes on to list a number of mental acts under each of these categories. Maybe it is because ‘caring thinking’ is not as common a term as ‘critical thinking’ and ‘creative thinking’ in everyday educational language that we stop for pause when we hear it. However when we read what Lipman says about caring thinking, we find ourselves nodding and saying to ourselves, ‘Yes, that makes sense. To think caringly means to think ethically, affectively, normatively, appreciatively and to actively participate in society with a concern for the common good’. In a real sense what we care about is manifest in how we perform, participate, build, contribute and how we relate to others. It is thinking that reveals our ideals as well as what we think is valuable, what we are willing to fight and suffer for. (shrink)

Focusing on the Groundwork and the Critique of Practical Reason, historical and contemporary critics of Kant's rationalist ethical theory accuse him of holding an impoverished moral psychology and an inadequate account of character and virtue. Kant's sharp contrast between duty and inclination and his claim that only action from duty possesses moral worth appear to imply that pro-moral inclination is unnecessary for, if perhaps compatible with, a good will. On traditional accounts of virtue, however, having a good will and possessing (...) virtue require pro-moral emotions and inclinations. Thus, Kant's moral psychology seems at odds with the common view that emotions and appetites are constituent elements within virtue. Kant's defenders have argued that an adequate assessment of these charges must address his theory of virtue, as it is set out in The Doctrine of Virtue, Religion within the Limits of Reason Alone, and the Lectures on Ethics. Yet the prospect for reconstructing a plausible Kantian account of virtue from these tests may appear bleak when we see that Kant conceives of virtue as moral strength of will over recalcitrant inclinations, and characterizes virtue in terms of the autocracy of pure practical reason. For autocracy may seem to require the extirpation or suppression of feelings and inclinations. Indeed, it might seem difficult to distinguish the autocratic agent from the agent who, in Aristotle's terms, is merely continent, or who, in Schiller's terms, possesses dignity, but not grace. But these objections misunderstand autocracy. In the thesis, I argue that the self-mastery constitutive of Kantian virtue involves the cultivation of sensibility according to reason and that emotions and appetites modified and regulated by a proper conception of the moral law play a constructive role within Kantian virtue. (shrink)

Against a widely-held interpretation of Kant’s political philosophy, according to which Kant holds that all finite rational beings have an innate right to freedom as well as a duty to enter into a civil condition governed by a social contract in order to preserve that freedom, Robert Hanna contends that Kant is in fact an anarchist. Hanna’s argument for his novel thesis that Kant ultimately views the State as an unjustifiably coercive institution that should be eliminated depends heavily on the (...) claim there is an outright conflict between Kant’s political theory in The Doctrine of Right and Kant’s ethics. I argue that we should resist Hanna’s provocative claim that Kant’s ethics directly falsifies his official political theory. Further, I suggest that even morally autonomous Kantian angels need the State to guarantee the protection of their external freedom and to promote justice. (shrink)

Biomedical science has been remarkably successful in explaining illness by categorizing diseases and then by identifying localizable lesions such as a virus and neoplasm in the body that cause those diseases. Not surprisingly, researchers have aspired to apply this powerful paradigm to addiction. So, for example, in a review of the neuroscience of addiction literature, Hyman and Malenka (2001, p. 695) acknowledge a general consensus among addiction researchers that “[a]ddiction can appropriately be considered as a chronic medical illness.” Like other (...) diseases, “Once addiction has taken hold, it tends to follow a chronic course.” (Koob and La Moal 2006, p. ?). Working from this perspective, much effort has gone into characterizing the symptomology of addiction and the brain changes that underlie them. Evidence for involvement of dopamine transmission changes in the ventral tegmental area (VTA) and nucleus accumbens (NAc) have received the greatest attention. Kauer and Malenka (2007, p. 844) put it well: “drugs of abuse can co-opt synaptic plasticity mechanisms in brain circuits involved in reinforcement and reward processing”. Our goal in this chapter to provide an explicit description of the assumptions of medical models, the different forms they may take, and the challenges they face in providing explanations with solid evidence of addiction. <br>. (shrink)

In this first part, Matthew Lipman offers the reader a glimpse at the thought processes that resulted in Philosophy for Children and, in so doing, ...